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Advances are occurring at a dizzying pace, and biotechnology has made an impact on many aspects of our everyday lives. Now in its third edition, Introduction to Biotechnology remains the first biotechnology textbook written specifically for the diverse backgrounds of undergraduate students. Aug 27, 2017 Biotechnology by satyanarayana pdf: Author of this great book is U. Satyanarayana biotechnology is very famous book of technology. Used in many countries as textbook especially in Asia. Many biotechnologist used this book and also recommended for students. The pdf is very helpful to study book on your Laptops, Mobile, PC. Feb 15, 2001 This book is printed on acid-free paper. Introduction to Biotechnology and Genetic Engineering. ISBN: 978-1-934015-16-2 The publisher recognizes and respects all marks used by companies, manufacturers, and developers as a means to distinguish their products. All brand names and product names mentioned in this book. Pazdernik, Ph.D. Is a co-author of Biotechnology, 2nd edition and Molecular Biology, 2nd edition, with Dr. The second edition of Molecular Biology won a Texty award from the Textbook and Academic Authors Association in 2013. She has also authored an on-line study guide to accompany the update edition of Molecular Biology. Biotechnology Introduction O ne of the newest, yet controversial fields in science today is biotechnology. Biotechnology began in the 1970s after the development of genetic engineering that allowed scientists to m odify the genetic material of living cells. Genetic engineer ing is the manipulation of DNA.
Book Preface
It is hard to imagine a more exciting time to be studying biotechnology. Advances are occurring at a dizzying pace, and biotechnology has made an impact on many aspects of our everyday lives. Now in its third edition, Introduction to Biotechnology remains the first biotechnology textbook written specifically for the diverse backgrounds of undergraduate students.
Appropriate for students at both 2- and 4-year and vocational technical schools, Introduction to Biotechnology
provides students with the tools for practical success in the biotechnology industry through its balanced coverage of molecular biology, details on contemporary techniques and applications, integration of ethical issues, and career guidance. Introduction to Biotechnology was designed with several major goals in mind. The text aims to provide:
provides students with the tools for practical success in the biotechnology industry through its balanced coverage of molecular biology, details on contemporary techniques and applications, integration of ethical issues, and career guidance. Introduction to Biotechnology was designed with several major goals in mind. The text aims to provide:
■ An engaging and easy-to-understand narrative that is appropriate for a diverse student audience with varying levels of scientific knowledge.
■ Assistance to instructors teaching all major areas of biotechnology and help to students learning fundamental scientific concepts without overwhelming and excessive detail.
■ An overview of historic applications while emphasizing modern, cutting-edge, and emerging areas of biotechnology.
■ Insights on how biotechnology applications can provide some of the tools to solve important scientific and societal problems for the benefit of humankind and the environment.
■ Inspiration for students to ponder the many ethical issues associated with biotechnology.
■ Assistance to instructors teaching all major areas of biotechnology and help to students learning fundamental scientific concepts without overwhelming and excessive detail.
■ An overview of historic applications while emphasizing modern, cutting-edge, and emerging areas of biotechnology.
■ Insights on how biotechnology applications can provide some of the tools to solve important scientific and societal problems for the benefit of humankind and the environment.
■ Inspiration for students to ponder the many ethical issues associated with biotechnology.
Introduction to Biotechnology provides broad coverage of topics including molecular biology, bioinformatics, genomics, and proteomics. We have striven to incorporate balanced coverage of basic molecular biology with practical and contemporary applications of biotechnology to provide students with the tools and knowledge they need to understand the field. In our effort to introduce students to the cuttingedge techniques and applications of biotechnology, we have dedicated specific chapters to such emerging areas as agricultural biotechnology (Chapter 6), forensic biotechnology (Chapter 8), bioremediation (Chapter 9), and aquatic biotechnology (Chapter 10). Consideration of the many regulatory agencies and issues that affect the biotechnology industry are discussed in Chapter 12. In addition to the ethical issues included in each chapter as You Decide boxes, a separate chapter (Chapter 13) is dedicated to ethics and biotechnology.
New Features of the Third Edition
The third edition of Introduction to Biotechnology includes several new instructor resources and exciting features:
■ Forecasting the Future briefly highlights exciting new areas of biotechnology that the authors predict will be worth watching in the future.
■ Making a Difference at the end of each chapter spotlights particularly beneficial aspects of biotechnology applications that have had major impacts in improving the quality of life.
■ More end-of-chapter Questions & Activities, including more Internet-based exercises.
■ A computerized test bank with multiple-choice questions for each chapter; electronic files for all images in the textbook; and PowerPoint Lecture Outline slides conveniently located on the Instructor’s Resource Center, www.pearsonhighered .com/educator.
■ New You Decide entries have been added to stimulate student interest in controversial areas of biotechnology.
■ Forecasting the Future briefly highlights exciting new areas of biotechnology that the authors predict will be worth watching in the future.
■ Making a Difference at the end of each chapter spotlights particularly beneficial aspects of biotechnology applications that have had major impacts in improving the quality of life.
■ More end-of-chapter Questions & Activities, including more Internet-based exercises.
■ A computerized test bank with multiple-choice questions for each chapter; electronic files for all images in the textbook; and PowerPoint Lecture Outline slides conveniently located on the Instructor’s Resource Center, www.pearsonhighered .com/educator.
■ New You Decide entries have been added to stimulate student interest in controversial areas of biotechnology.
In addition, each chapter has been thoroughly revised and updated to provide students with current information on emerging areas of biotechnology. Of special note are the following changes:
■ Chapter 1: The Biotechnology Century and Its Workforce. Includes updated content on the current state of the biotechnology industry, company mergers, biotechnology and pharmaceutical company revenues, funding sources for starting a biotechnology company, and investigational new drugs.
■ Chapter 2: An Introduction to Genes and Genomes. Includes a new section titled “Revealing the Epigenome,” which provides an introduction to epigenetics and its importance to genetic diseases and disease treatments.
■ Chapter 3: Recombinant DNA Technology and Genomics. Includes updated content on the Human Genome Project, a new section called “10 Years after the Human Genome Project,” and new coverage of the Genome 10K Plan, Human Microbiome Project, and personalized genomics. Major content updates have been made to DNA sequencing technologies, including a new section and figure titled “Next-Generation Sequencing.”
■ Chapter 4: Proteins as Products. Includes examples of delivery vehicles for proteins that overcome the difficulty of administering protein drugs; progress on designing protein structures based on the 1,200 superfamilies that have been discovered; the increased emphasis on discovery of biomarker proteins that can indicate disease at earlier stages; and the design of nanoparticles that deliver proteins designed to attach to sites on cancer cells to destroy them.
■ Chapter 5: Microbial Biotechnology, includes new content on metagenomics, the Human Microbiome Project, a new section on synthetic genomes, and a new section on microbes for making biofuels.
■ Chapter 6: Plant Biotechnology Includes the work of nonprofit research groups in developing new varieties of transgenic plants; the shift in emphasis to plant transgenic crops in developing countries, which are now the majority users; the addition of new transgenic crops and the expansion of others to include stacks of traits; new emphasis on different biofuels from plant wastes and algae; progress in biopharming, edible vaccines, and their importance; and current ways of dealing with resistant insects and weeds that have developed from the use of these crops.
■ Chapter 7: Animal Biotechnology. Includes a shift in direction from drugs to vaccines for humans of all ages and the rationale behind it; the significance of animal testing for drugs toward treatments for animal diseases; the benefits of cellculture testing before animal testing for regulatory approval; the first approval of a drug produced in a transgenic goat to treat a type of stroke; new method for creating animals with gene knockouts and knock-ins; and the importance of a national project to determine the function of all the genes in a rat by using knockout technology.
■ Chapter 8: DNA Fingerprinting and Forensic Analysis. Includes the progress in utilizing personal DNA sequencing as a precursor to diagnosis; the shift from RFLP to PCR fingerprinting and the reasoning behind it; new examples of DNA fingerprint comparisons using the CODIS sites; new examples of DNA sequences to identify certified products; and new examples of nonhuman DNA comparisons.
■ Chapter 9: Bioremediation. Includes updated content of GM species for bioremediation and a new section highlighting the roles of bioremediation in cleanup at the Deepwater Horizon oil spill in the Gulf of Mexico.
■ Chapter 10: Aquatic Biotechnology. Includes revised content on aquaculture, bioprospecting, and biotechnology products from aquatic organisms.
■ Chapter 11: Medical Biotechnology. Includes reorganized and revised content on the Human Genome Project and genetic testing along with a new section on direct-to-consumer genetic tests, updated content on gene therapy technologies, and new and updated content on induced-pluripotent stem cells and stem cell regulations.
■ Chapter 12: Biotechnology Regulations. Includes a discussion of the uses and dangers of synthetic genomes and potential regulations; the potential for faster drug approvals through the sharing of information on drug failures in trials; effect of FDA publication of long-term effects of previously approved drugs; the effect of the USPTO’s decision that gene sequences for diagnostic purposes are not patentable; new FDA policies designed to protect participants in drug trials; and the importance of current training of biotech company employees based on examples.
■ Chapter 13: Ethics and Biotechnology. Includes reorganized content and an abbreviated chapter format, new information on risk assessments, and a new You Decide on field trials of GM insects.
■ Chapter 2: An Introduction to Genes and Genomes. Includes a new section titled “Revealing the Epigenome,” which provides an introduction to epigenetics and its importance to genetic diseases and disease treatments.
■ Chapter 3: Recombinant DNA Technology and Genomics. Includes updated content on the Human Genome Project, a new section called “10 Years after the Human Genome Project,” and new coverage of the Genome 10K Plan, Human Microbiome Project, and personalized genomics. Major content updates have been made to DNA sequencing technologies, including a new section and figure titled “Next-Generation Sequencing.”
■ Chapter 4: Proteins as Products. Includes examples of delivery vehicles for proteins that overcome the difficulty of administering protein drugs; progress on designing protein structures based on the 1,200 superfamilies that have been discovered; the increased emphasis on discovery of biomarker proteins that can indicate disease at earlier stages; and the design of nanoparticles that deliver proteins designed to attach to sites on cancer cells to destroy them.
■ Chapter 5: Microbial Biotechnology, includes new content on metagenomics, the Human Microbiome Project, a new section on synthetic genomes, and a new section on microbes for making biofuels.
■ Chapter 6: Plant Biotechnology Includes the work of nonprofit research groups in developing new varieties of transgenic plants; the shift in emphasis to plant transgenic crops in developing countries, which are now the majority users; the addition of new transgenic crops and the expansion of others to include stacks of traits; new emphasis on different biofuels from plant wastes and algae; progress in biopharming, edible vaccines, and their importance; and current ways of dealing with resistant insects and weeds that have developed from the use of these crops.
■ Chapter 7: Animal Biotechnology. Includes a shift in direction from drugs to vaccines for humans of all ages and the rationale behind it; the significance of animal testing for drugs toward treatments for animal diseases; the benefits of cellculture testing before animal testing for regulatory approval; the first approval of a drug produced in a transgenic goat to treat a type of stroke; new method for creating animals with gene knockouts and knock-ins; and the importance of a national project to determine the function of all the genes in a rat by using knockout technology.
■ Chapter 8: DNA Fingerprinting and Forensic Analysis. Includes the progress in utilizing personal DNA sequencing as a precursor to diagnosis; the shift from RFLP to PCR fingerprinting and the reasoning behind it; new examples of DNA fingerprint comparisons using the CODIS sites; new examples of DNA sequences to identify certified products; and new examples of nonhuman DNA comparisons.
■ Chapter 9: Bioremediation. Includes updated content of GM species for bioremediation and a new section highlighting the roles of bioremediation in cleanup at the Deepwater Horizon oil spill in the Gulf of Mexico.
■ Chapter 10: Aquatic Biotechnology. Includes revised content on aquaculture, bioprospecting, and biotechnology products from aquatic organisms.
■ Chapter 11: Medical Biotechnology. Includes reorganized and revised content on the Human Genome Project and genetic testing along with a new section on direct-to-consumer genetic tests, updated content on gene therapy technologies, and new and updated content on induced-pluripotent stem cells and stem cell regulations.
■ Chapter 12: Biotechnology Regulations. Includes a discussion of the uses and dangers of synthetic genomes and potential regulations; the potential for faster drug approvals through the sharing of information on drug failures in trials; effect of FDA publication of long-term effects of previously approved drugs; the effect of the USPTO’s decision that gene sequences for diagnostic purposes are not patentable; new FDA policies designed to protect participants in drug trials; and the importance of current training of biotech company employees based on examples.
■ Chapter 13: Ethics and Biotechnology. Includes reorganized content and an abbreviated chapter format, new information on risk assessments, and a new You Decide on field trials of GM insects.
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Description
Biotechnology, Second Edition approaches modern biotechnology from a molecular basis, which has grown out of increasing biochemical understanding of genetics and physiology. Using straightforward, less-technical jargon, Clark and Pazdernik introduce each chapter with basic concepts that develop into more specific and detailed applications. This up-to-date text covers a wide realm of topics including forensics, bioethics, and nanobiotechnology using colorful illustrations and concise applications. In addition, the book integrates recent, relevant primary research articles for each chapter, which are presented on an accompanying website. The articles demonstrate key concepts or applications of the concepts presented in the chapter, which allows the reader to see how the foundational knowledge in this textbook bridges into primary research. This book helps readers understand what molecular biotechnology actually is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future.
- Up-to-date text focuses on modern biotechnology with a molecular foundation
- Includes clear, color illustrations of key topics and concept
- Features clearly written without overly technical jargon or complicated examples
- Provides a comprehensive supplements package with an easy-to-use study guide, full primary research articles that demonstrate how research is conducted, and instructor-only resources
Readership
Upper division undergraduates in microbiology, physiology, biology, pharmacology, biotechnology, zoology, plant biology, biochemistry and agriculture
Chapter 1. Basics of Biotechnology
- Advent of the Biotechnology Revolution
- Chemical Structure of Nucleic Acids
- Packaging of Nucleic Acids
- Bacteria as the Workhorses of Biotechnology
- Escherichia coli Is the Model Bacterium
- Many Bacteria Contain Plasmids
- Other Bacteria in Biotechnology
- Basic Genetics of Eukaryotic Cells
- Yeast and Filamentous Fungi in Biotechnology
- Yeast Mating Types and Cell Cycle
- Multicellular Organisms as Research Models
- Animal Cell Culture in Vitro
- Arabidopsis thaliana, a Model Flowering Plant
- Viruses Used in Genetics Research
- Subviral Infectious Agents and Other Gene Creatures
- Summary
Chapter 2. DNA, RNA, and Protein
- The Central Dogma of Molecular Biology
- Transcription Expresses Genes
- Making RNA
- Transcription Stop Signals
- The Number of Genes on an mRNA Varies
- Eukaryotic Transcription is More Complex
- Regulation of Transcription in Prokaryotes
- Regulation of Transcription in Eukaryotes
- Eukaryotic mRNA is Processed Before Making Protein
- Translating the Genetic Code into Proteins
- Differences between Prokaryotic and Eukaryotic Translation
- Mitochondria and Chloroplasts Synthesize Their Own Proteins
- Summary
Chapter 3. Recombinant DNA Technology
- DNA Isolation and Purification
- Electrophoresis Separates DNA Fragments by Size
- Restriction Enzymes Cut DNA; Ligase Joins DNA
- Methods of Detection for Nucleic Acids
- Complementary Strands Melt Apart and Reanneal
- Hybridization of DNA or RNA in Southern and Northern Blots
- Fluorescence in Situ Hybridization (FISH)
- General Properties of Cloning Vectors
- Specific Types of Cloning Vectors
- Getting Cloned Genes into Bacteria by Transformation
- Constructing a Library of Genes
- Screening the Library of Genes by Hybridization
- Eukaryotic Expression Libraries
- Features of Expression Vectors
- Recombineering Increases the Speed of Gene Cloning
- Gateway® Cloning Vectors
- Summary
Chapter 4. DNA Synthesis In Vivo and In Vitro
- Introduction
- Replication of DNA
- Comparing Replication in Gene Creatures, Prokaryotes, and Eukaryotes
- In Vitro DNA Synthesis
- Chemical Synthesis of DNA
- Chemical Synthesis of Complete Genes
- Polymerase Chain Reaction Uses in Vitro Synthesis to Amplify Small Amounts of DNA
- Modifications of Basic PCR
- Reverse Transcriptase PCR
- PCR in Genetic Engineering
- PCR of DNA can Determine the Sequence of Bases
- Next-Generation Sequencing Technologies
- Summary
Chapter 5. RNA-Based Technologies
- Noncoding RNA Plays Many Roles
- RNA Coordinates Genomic Integrity in Eukaryotes
- RNA Protects Genomes from Invading Viruses
- RNA Modulates Transcription
- Noncoding RNAs Take Part in RNA Processing
- Riboswitches are Controlled by Effector Molecules
- RNA Catalyzes Enzyme Reactions
- Summary
Chapter 6. Immune Technology
- Introduction
- Antibodies, Antigens, and Epitopes
- The Great Diversity of Antibodies
- Structure and Function of Immunoglobulins
- Monoclonal Antibodies for Clinical Use
- Humanization of Monoclonal Antibodies
- Humanized Antibodies in Clinical Applications
- Antibody Engineering
- Diabodies and Bispecific Antibody Constructs
- ELISA Assay
- The ELISA as a Diagnostic Tool
- Visualizing Cell Components using Antibodies
- Fluorescence-Activated Cell Sorting
- Immune Memory and Vaccination
- Creating a Vaccine
- Making Vector Vaccines using Homologous Recombination
- Reverse Vaccinology
- Identifying New Antigens for Vaccines
- DNA Vaccines Bypass the need to Purify Antigens
- Edible Vaccines
- Summary
Chapter 7. Nanobiotechnology
- Introduction
- Visualization at the Nanoscale
- Scanning Tunneling Microscopy
- Atomic Force Microscopy
- Weighing Single Bacteria and Virus Particles
- Nanoparticles and Their Uses
- Nanoparticles for Labeling
- Quantum Size Effect and Nanocrystal Colors
- Nanoparticles for Delivery of Drugs, DNA, or RNA
- Nanoparticles in Cancer Therapy
- Assembly of Nanocrystals by Microorganisms
- Nanotubes
- Antibacterial Nanocarpets
- Detection of Viruses by Nanowires
- Ion Channel Nanosensors
- Nanoengineering of DNA
- DNA Origami
- DNA Mechanical Nanodevices
- Controlled Denaturation of DNA by Gold Nanoparticles
- Controlled Change of Protein Shape by DNA
- Biomolecular Motors
- Summary
Chapter 8. Genomics and Gene Expression
- Introduction
- Genetic Mapping Techniques
- Gaps Remain in the Human Genome
- Survey of the Human Genome
- Noncoding Components of the Human Genome
- Bioinformatics and Computer Analysis
- Medicine and Genomics
- DNA Accumulates Mutations over Time
- Genetic Evolution
- From Pharmacology to Pharmacogenetics
- Gene Expression and Microarrays
- Making DNA Microarrays
- Hybridization ON DNA Microarrays
- Monitoring Gene Expression Using Whole-Genome Tiling Arrays
- Monitoring Gene Expression by RNA-Seq
- Monitoring Gene Expression of Single Genes
- Epigenetics and Epigenomics
- Epigenomics in Higher Organisms
- Summary
Iso norm 9241 teil 210. Chapter 9. Proteomics
- Introduction
- Gel Electrophoresis of Proteins
- Western Blotting of Proteins
- High-Pressure Liquid Chromatography Separates Protein Mixtures
- Digestion of Proteins by Proteases
- Mass Spectrometry for Protein Identification
- Preparing Proteins for Mass Spectroscopy
- Protein Quantification Using Mass Spectrometry
- Protein Tagging Systems
- Phage Display Library Screening
- Protein Interactions: The Yeast Two-Hybrid System
- Protein Interactions by Co-immunoprecipitation
- Protein Arrays
- Metabolomics
- Summary
Chapter 10. Recombinant Proteins
- Proteins and Recombinant DNA Technology
- Expression of Eukaryotic Proteins in Bacteria
- Insulin and Diabetes
- Cloning and Genetic Engineering of Insulin
- Translation Expression Vectors
- Codon Usage Effects
- Avoiding Toxic Effects of Protein Overproduction
- Inclusion Bodies and Protein Refolding
- Increasing Protein Stability
- Improving Protein Secretion
- Protein Fusion Expression Vectors
- Protein Glycosylation
- Expression of Proteins by Eukaryotic Cells
- Expression of Proteins by Yeast
- Expression of Proteins by Insect Cells
- Expression of Proteins by Mammalian Cells
- Expression of Multiple Subunits in Mammalian Cells
- Comparing Expression Systems
- Summary
Chapter 11. Protein Engineering
- Introduction
- Engineering Disulfide Bonds
- Improving Stability In Other Ways
- Changing Binding Site Specificity
- Structural Scaffolds
- Directed Evolution
- Recombining Domains
- DNA Shuffling
- Combinatorial Protein Libraries
- Creation of De Novo Proteins
- Expanding the Genetic Code
- Roles of Non-Natural Amino Acids
- Biomaterials Design Relies on Protein Engineering
- Engineered Binding Proteins
- Summary
Chapter 12. Environmental Biotechnology
- Introduction
- Identifying New Genes with Metagenomics
- Culture Enrichment for Environmental Samples
- Sequence-Dependent Techniques for Metagenomics
- Function- or Activity-Based Evaluation of The Environment
- Ecology and Metagenomics
- Natural Attenuation of Pollutants
- Biofuels and Bioenergy
- Microbial Fuel Cells
- Summary
A Review Of Biotechnology Pdf
Chapter 13. Synthetic Biology
- Introduction
- Ethanol, Elephants, and Pathway Engineering
- Degradation of Starch
- Degradation of Cellulose
- Second-Generation Biofuels
- Biodiesel
- Ice-Forming Bacteria and Frost
- Biorefining of Fossil Fuels
- Biosynthesis of β-Lactam Antibiotics
- Biosynthetic Plastics are Also Biodegradable
- The Integrated Circuits Approach
- Synthetic Genetic Materials: xDNA And XNA
- Designer Bacteria
- Summary
Chapter 14. From Cell Phones to Cyborgs
- Introduction
- Cell Phones
- Robotics
- Radio-Controlled Genes
- Insect Cyborgs
- Soft Robotics
- Summary
Chapter 15. Transgenic Plants and Plant Biotechnology
- Introduction
- History of Plant Breeding
- Plant Tissue Culture
- Genetic Engineering of Plants
- Biotechnology Improves Crops
- Resistance: Nature Responds to Transgenic Plants
- Functional Genomics in Plants
- Summary
Chapter 16. Transgenic Animals
- New and Improved Animals
- Creating Transgenic Animals
- Larger Mice Illustrate Transgenic Technology
- Recombinant Protein Production Using Transgenic Livestock
- Knockout Mice for Medical Research
- Alternative Ways to Make Transgenic Animals
- Location Effects on Expression of the Transgene
- Deliberate Control of Transgene Expression
- Gene Control by Site-Specific Recombination
- Transgenic Insects
- Practical Transgenic Animals
- Applications of RNA Technology in Transgenics
- Natural Transgenics and DNA Ingestion
- Summary
Chapter 17. Inherited Defects and Gene Therapy
- Introduction
- Hereditary Defects in Higher Organisms
- Hereditary Defects Due to Multiple Genes
- Defects Due to Haploinsufficiency
- Dominant Mutations may be Positive or Negative
- Deleterious Tandem Repeats and Dynamic Mutations
- Defects in Imprinting and Methylation
- Mitochondrial Defects
- Identification of Defective Genes
- Genetic Screening and Counseling
- General Principles of Gene Therapy
- Adenovirus Vectors in Gene Therapy
- Cystic Fibrosis
- Cystic Fibrosis Gene Therapy
- Retrovirus Gene Therapy
- Retrovirus Gene Therapy for Scid
- Adeno-Associated Virus
- Nonviral Delivery in Gene Therapy
- Liposomes and Lipofection in Gene Therapy
- Aggressive Gene Therapy for Cancer
- Using RNA in Therapy
- Antisense RNA and Other Oligonucleotides
- Aptamers—Blocking Proteins with DNA or RNA
- Ribozymes in Gene Therapy
- RNA Interference in Gene Therapy
- Gene Editing with Nucleases
- Genome Editing with Engineered Nucleases
- Genome Editing with CRISPR Nucleases
- Summary
Chapter 18. Cloning and Stem Cells
- Introduction
- What is a Stem Cell?
- Identifying Adult Stem Cells
- The Key Features of a Stem Cell Niche
- Hematopoietic Stem Cells in the Bone Marrow
- Intestinal Epithelial Stem Cells
- Induced Pluripotent Stem Cells
- Stem Cell Therapy
- Somatic Cell Nuclear Transfer
- Dolly the Cloned Sheep
- Practical Reasons for Cloning Animals
- Improving Livestock by Pathway Engineering
- Imprinting and Developmental Problems in Cloned Animals
- Summary
Chapter 19. Cancer
- Cancer is Genetic in Origin
- Environmental Factors and Cancer
- Normal Cell Division: The Cell Cycle
- Cellular Communication
- Receptors and Signal Transmission
- Cell Division Responds to External Signals
- Genes that Affect Cancer
- Oncogenes and Proto-Oncogenes
- Detection of Oncogenes by Transformation
- Types of Mutations that Generate Oncogenes
- The RAS Oncogene—Hyperactive Protein
- The MYC Oncogene—Overproduction of Protein
- Tumor-Suppressor Genes or Anti-Oncogenes
- The p16, p21, and p53 Anti-Oncogenes
- Formation of a Tumor
- Inherited Susceptibility to Cancer
- Cancer-Causing Viruses
- Engineered Cancer-Killing Viruses
- Cancer Genomics
- Cancer Epigenomics
- Micro RNA Regulation and Cancer
- Anticancer Agents
- Summary
Chapter 20. Aging and Apoptosis
- Introduction
- Genetic Phenomena Associated with Aging
- Cellular Dysfunction and Aging
- Cellular Senescence
- Programmed Cell Death
- Apoptosis Involves a Proteolytic Cascade
- Mammalian Apoptosis
- Caspases
- Execution Phase of Apoptosis
- Corpse Clearance in Apoptosis
- Control of Apoptotic Pathways in Development
- Necroptosis
- Metabolic Control of Cell Death
- Cancer, Aging, and Programmed Cell Death
- Programmed Cell Death in Bacteria
- Summary
Chapter 21. Viral and Prion Infections
- Viral Infections and Antiviral Agents
- Interferons Coordinate the Antiviral Response
- Antiviral Therapy using RNA Interference
- Influenza is a Negative-Strand Rna Virus
- The AIDS Retrovirus
- Chemokine Receptors Act as Co-Receptors for Hiv
- Treatment of the AIDS Retrovirus
- Infectious Prion Disease
- Detection of Pathogenic Prions
- Approaches to Treating Prion Disease
- Prions in Yeast
- Using Yeast Prions as Models
- Amyloid Proteins in Neurological Diseases
- Summary
Chapter 22. Biological Warfare: Infectious Disease and Bioterrorism
- Introduction
- The Natural History of Biological Warfare
- Microbes Versus Man: The Rise of Antibiotic Resistance
- A Brief History of Human Biological Warfare
- Identifying Suitable Biological Warfare Agents
- A Closer Look at Select Biological Warfare Agents
- Enhancing Biological Warfare Agents with Biotechnology
- Detection of Biological Warfare Agents
- Summary
Chapter 23. Forensic Molecular Biology
- The Genetic Basis of Identity
- Blood, Sweat, and Tears
- Forensic DNA Testing
- DNA Fingerprinting
- Using Repeated Sequences in Fingerprinting
- Probability and DNA Testing
- The Use of DNA Evidence
- DNA is Also Used to Identify Animals
- Tracing Genealogies by Mitochondrial DNA and the Y Chromosome
- Identifying the Remains of the Russian Imperial Family
- Gene Doping and Athletics
- Genomics Drives Advances in Forensics
- Summary
Chapter 24. Bioethics in Biotechnology
- Introduction
- Principles of Bioethics
- Use of the Precautionary Principle
- The Power of Information
- Possible Dangers to Health from Biotechnology
- Genetically Modified Organisms
- Human Enhancement, Cloning, and Engineering
- Ethics Changes over Time
- Summary
Details
- No. of pages:
- 850
- Language:
- English
- Copyright:
- © Academic Cell 2016
- Published:
- 25th June 2015
- Imprint:
- Academic Cell
- Hardcover ISBN:
- 9780123850157
- eBook ISBN:
- 9780123850164
David Clark
David P. Clark did his graduate work on bacterial antibiotic resistance to earn his Ph.D. from Bristol University, in the West of England. During this time, he visited the British Government's biological warfare facility at Porton Down and was privileged to walk inside the (disused) Black Death fermenter. Download directx 11 2. He later crossed the Atlantic to work as a postdoctoral researcher at Yale University and then the University of Illinois. David Clark recently retired from teaching Molecular Biology and Bacterial Physiology at Southern Illinois University which he joined in 1981. His research into the Regulation of Alcohol Fermentation in E. coli was funded by the U.S. Department of Energy, from 1982 till 2007. From 1984-1991 he was also involved in a project to use genetically altered bacteria to remove contaminating sulfur from coal, jointly funded by the US Department of Energy and the Illinois Coal Development Board. In 1991 he received a Royal Society Guest Research Fellowship to work at Sheffield University, England while on sabbatical leave. He has supervised 11 master’s and 7 PhD students and published approximately 70 articles in scientific journals. He has written or co-authored several textbooks, starting with Molecular Biology Made Simple and Fun (with Lonnie Russell; (Cache River Press, First edition, 1997) which is now in its fourth edition. Other books are Molecular Biology and Biotechnology (both published by Elsevier) He recently wrote a popular science book, Germs, Genes, & Civilization: How Epidemics Shaped Who We Are Today (2010, Financial Times Press/Pearson). David is unmarried, but his life is supervised by two cats, Little George and Mr Ralph.
Southern Illinois University, Carbondale, Illinois, USA
Nanette Pazdernik
Nanette J. Pazdernik, Ph.D. is a co-author of Biotechnology, 2nd edition and Molecular Biology, 2nd edition, with Dr. David Clark. The second edition of Molecular Biology won a Texty award from the Textbook and Academic Authors Association in 2013. She has also authored an on-line study guide to accompany the update edition of Molecular Biology. She has taught courses in General Biology, Genetics, as well as Anatomy and Physiology at Southwestern Illinois College, McKendree University, and Harris-Stowe University. She received her BA in Biology from Lawrence University in Appleton, Wisconsin, in 1990 and her PhD in Molecular, Cellular, Developmental Biology and Genetics from the University of Minnesota in 1996. Her doctoral thesis studied how alterations in the structure of lactose permease affect its ability to transport sugar across the membrane of E. coli. Following her degrees, she investigated the IL-1 and TNF signal transduction pathways that control apoptosis and immunity at Indiana University School of Medicine. She has most recently studied the various molecules that maintain the stem cell fate in C. elegans at Washington University School of Medicine in St. Louis, MO. She is married and the mother of three children, ages 15, 12, and 8, which always make her realize the role biology plays in personality and development!
Washington University School of Medicine, St. Louis, Missouri, USA
Awards
2016 TAA Textbook Awards - Winner, 2016 Textbook Excellence Award (“Texty”): Textbook & Academic Authors Association Active directory powershell module windows 10 download.
Biotechnology, Second Edition approaches modern biotechnology from a molecular basis, which has grown out of increasing biochemical understanding of genetics and physiology. Using straightforward, less-technical jargon, Clark and Pazdernik introduce each chapter with basic concepts that develop into more specific and detailed applications. This up-to-date text covers a wide realm of topics including forensics, bioethics, and nanobiotechnology using colorful illustrations and concise applications. In addition, the book integrates recent, relevant primary research articles for each chapter, which are presented on an accompanying website. The articles demonstrate key concepts or applications of the concepts presented in the chapter, which allows the reader to see how the foundational knowledge in this textbook bridges into primary research. This book helps readers understand what molecular biotechnology actually is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future.'> Powered by
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Ssalehhamed5 star rating
On Biotechnology
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MMichaelDueck4 star rating
I frankly didn't know what to expect from this textbook. While I'm not affiliated with any institution, I'm an autodidact with interest in genetics and biochemistry.
This book gives an excellent, thorough introduction to a very broad swathe of categories. It is not a specialist book, as that is intended by the authors I believe (biotechnology, the text mentions, is a huge multidisciplinary field). What it was good for was bridging my recent microbiology and chemistry exposure and showing me applications in the real world. It also gives a good image of possibilities and current limitations, as well as areas of research that I may potentially pursue.
While this was great, I have to deduct some points for the lack of concrete data contained in the textbook. It was clearly written for someone with minimal exposure to technical mathematics or statistics, perhaps for a first year student of biological sciences. That is both a blessing and a curse, as the takeaway from the text itself is a little nebulous. It certainly lacks any tangible biophysics component. Perhaps that was the intent, but it certainly makes me hanker for a little more data driven deliveries.
This book gives an excellent, thorough introduction to a very broad swathe of categories. It is not a specialist book, as that is intended by the authors I believe (biotechnology, the text mentions, is a huge multidisciplinary field). What it was good for was bridging my recent microbiology and chemistry exposure and showing me applications in the real world. It also gives a good image of possibilities and current limitations, as well as areas of research that I may potentially pursue.
While this was great, I have to deduct some points for the lack of concrete data contained in the textbook. It was clearly written for someone with minimal exposure to technical mathematics or statistics, perhaps for a first year student of biological sciences. That is both a blessing and a curse, as the takeaway from the text itself is a little nebulous. It certainly lacks any tangible biophysics component. Perhaps that was the intent, but it certainly makes me hanker for a little more data driven deliveries.
share' Share Review by MichaelDueck on 13 Aug 2019
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